CHICAGO (AP) - When Chris Sale takes the mound, left-handed batters usually try to take the night off.
Seattle Mariners manager Lloyd McClendon, though, decided to take a different approach - he had six lefties in the lineup.
Perhaps he would like to rethink that approach.
Sale struck out a season-high 12 and allowed just six hits in a complete-game performance and Jose Abreu hit his 27th home run to lead the Chicago White Sox to a 7-1 victory Friday night.
Sale (8-1) was aiming for his second career shutout before the Mariners pushed across a meaningless run in the ninth inning.
"He's one of the best in the league," McClendon said of Sale. "Lefty-righty, it really doesn't make a difference. Our lefties, for the most part, have handled lefties this year pretty good. This guy was special tonight. You tip your hat to him."
Before Friday, left-handed batters were just 4 for 45 (a batting average of .089) against the side-winding left-hander. The Mariners did manage four hits Friday (in 21 at-bats), but that was of little consolation.
"Listen, he was nasty tonight," McClendon said. "It was tough to see early on and he found his groove. He was pretty good. That's baseball. That's how it goes."
Sale walked none in his fourth double-digit strikeout game of the season and 14th of his career. His slider, which is usually good, was special on Friday.
"I knew warming up in the bullpen it was going to be a pretty good pitch for me tonight," Sale said. "I was really working on that tonight in the bullpen. I threw a few more in my pre-game bullpen than I usually do, just because I knew the amount of lefties. It's good to have that."
Dayan Viciedo and Paul Konerko also homered for the White Sox, who have won five of seven.
Willie Bloomquist went 2 for 4 for the Mariners, who saw their four-game winning streak snapped. Rookie Roenis Elias (7-7) allowed five runs in five innings. He struck out six and walked one.
Viciedo went 4 for 4 including a leadoff homer in the fourth that gave the White Sox a 1-0 lead. His 10th homer came on a 2-1 pitch.
The White Sox added four runs in the fifth. Adam Eaton hit an RBI double and Gordon Beckham followed with a sacrifice fly after Moises Sierra singled and Tyler Flowers was hit by a pitch.
Abreu then extended his hitting streak to 18 games with a two-run home run that put the White Sox ahead 5-0. He was tied for the major league lead for homers entering Friday. Abreu has eight home runs and 18 RBIs during his hitting streak, the longest active in the majors.
The Mariners put runners at second and third in the sixth after two singles and a wild pitch, but Sale struck out two to end the inning.
Konerko hit a two-run homer, his fifth, off Charlie Furbush for a 7-0 lead in the eighth.
Sale allowed a single to Bloomquist and a one-out double to Robinson Cano in the ninth. Sale stayed in the game after manager Robin Ventura visited the mound. He allowed a sacrifice fly to Corey Hart and got Kyle Seager to ground out to end the game.
Cano believes Sale's slider is the best he's seen.
"Every time I face him he's got the same slider," Cano said. "Sometimes you face a guy and one day he doesn't have it. This is a guy, he always has his slider. His slider is the best pitch he has. He confuses every lefty. You don't know when it's a fastball and when it's a slider."
NOTES: The Mariners activated DH Hart and 1B Justin Smoak from the 15-day DL before optioning Smoak to Triple-A Tacoma. Hart is also ready to play at first base or in the outfield, McClendon said. Hart missed seven weeks due to a strained left hamstring. ... Smoak hit .208 in 63 games before suffering a strained left quad. He went on the DL June 10 and hit .204 in 13 games during a rehab assignment with Tacoma. McClendon said Smoak will eventually return as a start. ... Mariners RHP Felix Hernandez (10-2, 2.10) will start against White Sox LHP Jose Quintana (5-7, 3.44) on Saturday.