Week 5: Oct. 6, 10:00 a.m. - Seahawks at Colts
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It will be a battle of two 2012 Rookie of the Year finalists as former No. 1 overall draft pick Andrew Luck and the Colts host Russell Wilson and the Seahawks. It will be the Colts' first full season under head coach Chuck Pagano, who took several games off while battling cancer.