Italy's highest court on Monday is expected to decide whether to overturn the acquittals of Amanda Knox and Raffaele Sollecito.
An appeals court cleared the two of the murder of Meredith Kercher, Knox's roommate in Perugia, in 2011.
Knox was freed after spending four years in prison. Knox’s Italian ex-boyfriend was also exonerated on the murder charges. The court ruled there was no conclusive evidence of the pair’s involvement in Kercher’s death.
Knox is now living in Seattle, where she is keeping a low profile and working on writing her memoir. Publishing House HarperCollins won the fierce bidding war, reportedly paying $4 million for Knox’s story. The book is scheduled for release at the end of April.
The crime and trial drew worldwide attention and criticism in the United States of the Italian legal system.
Neither Knox nor Sollecito will be present in court Monday.
Kercher's sister told the Daily Mail that the final court hearing must address "unanswered questions" about the murder.
Knox and Sollecito face a retrial if prosecutors win their appeal.
Rudy Guede is serving 16 years for the murder of Kercher.